Oral Administration of Garcinia dulcis Flower Extract Lowers Arterial Blood Pressure of 2-kidneys-1-clip Renovascular Hypertensive Rat

The hexane insoluble fraction of the Garcinia dulcis (GD) flower extract comprises mainly camboginol and morelloflavone which possess potent in vivo vitro antioxidant properties. This study aimed to evaluate effects 4-week oral administration GD on arterial blood pressure (ABP) excretory function kidney 2-kidneys-1-clip (2K1C) renovascular hypertensive rats (total=12) compared sham operated (SO) normotensive Wistar (total=12). Four weeks after hypertensive-induced surgery, either 50 mg/kg BW or vehicle was orally administered 2K1C SO groups (n=6/group) daily for four weeks. ABP renal were studied anesthetized rats, expression endothelial nitric oxide synthase (eNOS) mRNA isolated thoracic aorta measured. In significantly decreased while increased eNOS levels. did not exert a diuretic effect since there no change observed urine excretion, but it tend attenuated tubular damage caused by hypertension. anti-hypertensive this model hypertension problably acts via signaling pathway.